Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue

Monguia, Alvaro; Perez-Leal, Oscar; Rojas-Caraballo, Jose; Angel, Diana I.; Cortes, Jimena; Patarroyo, Manuel A.

doi:https://doi.org/10.1016/j.bbrc.2007.05.015

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Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue

https://repository.urosario.edu.co/handle/10336/25942
https://doi.org/10.1016/j.bbrc.2007.05.015

Autores

Monguia, Alvaro

Perez-Leal, Oscar

Rojas-Caraballo, Jose

Angel, Diana I.

Cortes, Jimena

Patarroyo, Manuel A.

Fecha

2007-07-06

Editor

Elsevier

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Abstract

Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P. falciparum RhopH3 is a rhoptry protein triggering important immune responses in patients from endemic regions. It has also been shown that anti-RhopH3 antibodies inhibit in vitro invasion of erythrocytes. Recent immunisation studies in mice with the Plasmodium yoelii and Plasmodium berghei RhopH3 P. falciparum homologue proteins found that they are able to induce protection in murine models. This study described identifying and characterising RhopH3 protein in Plasmodium vivax; it is encoded by a seven exon gene and expressed during the parasite’s asexual stage. PvRhopH3 has similar processing to its homologue in P. falciparum and presents a cellular immunolocalisation pattern characteristic of rhoptry proteins.