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The CCR5 delta 32 polymorphism (rs333) is not associated with Sjögren's syndrome or Type 1 Diabetes in Colombians
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Autores
Maier-Moore, Jacen S.
Cañas, Carlos A.
Tobón, Gabriel
Arango, Alvaro
Anaya, Juan-Manuel
Scofield, R. Hal
Fecha
2013-08-01
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Elsevier
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Abstract
Sjögren's syndrome (SS) and Type 1 Diabetes (T1D) are chronic, progressive autoimmune diseases that affect exocrine glands or ?-cells in the islets of Langerhans in the pancreas, respectively. Typical features of both diseases include production of antibodies against self-antigens and T and B cell infiltrates in organ-specific tissues [12] . Migration of pro-inflammatory memory T cells and monocytes into chronically inflamed tissues is driven by Th1-related chemokines and their receptors. This includes CCR5, a seven-transmembrane domain G protein-coupled receptor (GPCR) involved in intracellular signaling [3] . In Sjögren's syndrome, mRNA and receptor expression of CCR5 are significantly upregulated in inflammatory Th1 cells, parotid gland excretory ducts and conjunctival epithelium of SS-affected individuals indicating that it has a significant role in the progression and severity of pSS disease [45] . In Type 1 Diabetes, recruitment of activated CCR5-expressing T cells to the pancreas or kidney can promote renal disease and impairment of insulin production [6] .
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Keywords
Chemokine receptor CCR5 , DNA , Cell migration , Cell surface , Colombia , DNA polymorphism , Frameshift mutation , Gene deletion , Gene frequency , Genetic association , Genotype , Human , Insulin dependent diabetes mellitus , Letter , Leukocyte , Priority journal , Sjoegren syndrome , CCR5 delta 32 , Rs333 , Sjögren's syndrome , Type 1 Diabetes , Colombia , Diabetes Mellitus Type 1 , Genetic Predisposition to Disease , Humans , Polymorphism Genetic , Receptors CCR5 , Sjogren's Syndrome , CCR5 delta 32 , Rs333 , Sjögren's syndrome , Type 1 Diabetes
