Ítem
Solo Metadatos
Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
Título de la revista
Autores
Puentes, Alvaro
García, Javier
Vera, Ricardo
López, Ramsés
Suarez, Jorge
Rodríguez, Luis
Curtidor, Hernando
Ocampo, Marisol
Tovar, Diana
Forero, Martha
Fecha
2004-03-12
Directores
ISSN de la revista
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Editor
The Japanese Society for Vaccinology
Elsevier
Elsevier
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Resumen
Abstract
Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 () and 20611 () peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immune-fluorescence antibody test with 24276 (20608 peptide analogue, CGIWSKDEKAQGEESHCG) showed sporozoite and merozoite reactivity. This data suggests SALSA high activity binding peptides’ (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes.
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Keywords
Plasmodium falciparum , SALSA protein , Binding peptides , Critical residues , Hepatocyte binding peptides