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Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis
Título de la revista
Autores
Anaya, Juan-Manuel
Sany, J.
Canovas, F.
Combe, B
Jorgensen, C.
Saker, S
Fecha
1993
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Europe PMC
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Abstract
OBJECTIVE: To evaluate the influence of methotrexate (MTX) on the frequency of postoperative complications in patients with rheumatoid arthritis (RA). METHODS: We conducted a randomized unblinded prospective study in 64 patients with RA treated with MTX and who underwent orthopedic surgery. Two groups of patients were constituted: in Group A (32 patients), MTX was interrupted 7 days before the surgery; in Group B (32 patients), MTX was not discontinued. RESULTS: Fifty surgical procedures were performed in Group A and 39 procedures in Group B. No postoperative infection was observed in any group. A prolonged wound healing was noticed in 6 cases in Group A and in 4 cases in Group B (not significant). CONCLUSION: We suggest that the interruption of MTX is not required in patients with RA when an orthopedic surgical treatment is planned. However a large prospective study is needed to make a definitive conclusion.
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Keywords
Influence of methotrexate (MTX) , Rheumatoid arthritis
