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Hyperprolactinaemia in primary Sjogren's syndrome [1]
Título de la revista
Autores
Gutiérrez, M.A.
Anaya, Juan-Manuel
Scopelitis E.
Citera, G.
Silveira, L. H.
Espinoza, L.
Fecha
1994-01-01
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BMJ Publishing Group
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Resumen
Abstract
Prolactin (PRL) is a neuroendocrine hormone that has important immunoregulatory properties. It is a potent mitogen in Nb2 T lymphoma cell line and stimulates both T-cell mediated and humoral immunity.' Recently an association between hyperprolactinaemia and certain rheumatic diseases has been described suggesting that PRL may play a role in the pathogenesis of some autoimmune diseases.94 In addition, PRL seems to be an autocrine factor required for viability and proliferation of B lymphoma cells.5 Furthermore, it was recently proposed that hyperprolactinaemia observed in oestrogentreated mice may predispose to development of lymphoma in these animals.6 Primary Sj6gren's syndrome (P-SS) is a chronic autoimmune disease characterised by exocrine glandular insufficiency secondary to lymphocytic and plasma cell infiltration. The spectrum of the disease extends from an organ specific autoimmune disease to a systemic involvement.7 Characteristically, patients with Sjogren's syndrome (SS) have an increased risk of developing lymphoma.'
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Keywords
Hyperprolactinaemia , Primary Sjogren's syndrome
