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PROTECTIVE ROLE OF ACTIVATED PROTEIN C AGAINST APOPTOSIS IN NEURONAL AND ENDOTHELIAL MODELS
Título de la revista
Autores
Morales, L.C.
Díaz, J.
Camargo, M.H.
Arboleda, H.
Arboleda, G.
Matheus Merino, Luisa Marina
Fecha
2009-02-01
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John Wiley & Sons
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Abstract
The neurodegenerative diseases are the result of the interaction of several factors that converge in neuronal death. Neuronalapoptosis is believe to have a mayor physiophatological role in this process which is accompanied by alterations in thevascular brain endothelium, contributing to alterations in the blood-brain barrier, a key regulator of neuronal survival/death equilibrium. Increased levels of the sphingolipid ceramide have been described in diverse neurodegenerative disorders and following several cellular stress insults and is believe to contribute to thepathophysiology of neuronal death.
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Keywords
Neurodegenerative diseases , Neuronalapoptosis , Alterations in thevascular brain endothelium , Key regulator of neuronal survival/death equilibrium , Pathophysiology of neuronal death
