Ítem
Acceso Abierto
Obstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis
Título de la revista
Autores
Valli, Isabel
Gonzalez Segura, Alex
Verdolini, Norma
Garcia-Rizo, Clemente
Berge, Daniel
Baeza, Inmaculada
Cuesta, Manuel J.
Gonzalez-Pinto, Ana
Lobo, Antonio
Martinez-Aran, Anabel
Fecha
2023-02-27
Directores
ISSN de la revista
Título del volumen
Editor
Buscar en:
Métricas alternativas
Resumen
Antecedentes: Las complicaciones obstétricas (CO) son contribuyentes clave al riesgo de psicosis. Sin embargo, no está claro si aumentan la vulnerabilidad a la psicosis de manera independiente del riesgo genético, en interacción con él, o si son una manifestación de la propensión a la psicosis. Examinamos el papel de distintos tipos de CO en términos de riesgo de psicosis y probamos si interactúan de manera diferente con la vulnerabilidad genética, teniendo en cuenta otros factores de riesgo ambiental conocidos. Diseño del estudio: 405 participantes (219 pacientes con psicosis en el primer episodio y 186 voluntarios sanos) se sometieron a una evaluación integral de las CO, medidas utilizando la escala de Lewis-Murray y divididas en complicaciones de embarazo, anormalidades del crecimiento y desarrollo fetal, y complicaciones del parto. Se comparó a los participantes en términos de historia de CO, puntuación de riesgo poligénico para la esquizofrenia (PRS-SZ) e interacciones entre estos.
Abstract
Background: Obstetric complications (OCs) are key contributors to psychosis risk. However, it is unclear whether they increase psychosis vulnerability independently of genetic risk, in interaction with it, or are a manifestation of psychosis proneness. We examined the role of distinct types of OCs in terms of psychosis risk and tested whether they interact differently with genetic vulnerability, whilst accounting for other known environmental risk factors. Study Design: 405 participants (219 first episode psychosis patients and 186 healthy volunteers) underwent a comprehensive assessment of OCs, measured using the Lewis-Murray scale and divided into complications of pregnancy, abnormalities of foetal growth and development, and complications of delivery. Participants were compared in terms of history of OCs, polygenic risk score for schizophrenia (PRS-SZ) and interactions between these. Results: Both complications of pregnancy and abnormalities of foetal growth were significantly associated with case–control status (p = 0.02 and 0.03, respectively), whereas complications of delivery were not. PRS-SZ showed a significant association with psychosis (p = 0.04), but there were no significant interactions between genetic risk for schizophrenia and OCs, either when these were considered globally or separated based on their timeframe. Conclusions: We observed no significant interaction between genetic and obstetric vulnerability, yet distinct types of OCs may have a different impact
Palabras clave
Utero , Placenta
Keywords
Environmental , Funding , Polygenic risk score , Polygenic risk score , Pregnancy
